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(A) Example trace of sIPSC recordings performed with caesium chloride (CsCl) and in the presence of the AMPA and NMDA blockers <t>NBQX</t> <t>and</t> <t>DL-AP5,</t> respectively. (B) Boxplots of sIPSC frequency, amplitude, rise time, and decay time (frequency: 4.73 ± 2.09 Hz; amplitude:-62.5 ± 25.6 pA; rise time; 2.00 ± 0.31 ms; decay time: 5.27 ± 1.34 ms; n = 15 neurons from 5 mice). (C) Example traces of a recorded MDJ-IO neuron before (t=0), 10 minutes after (t=10), and 20 minutes (t=20) after the addition of the GABA receptor blocker picrotoxin (PTX). (D) Time-course of the frequency minutes (F(1,6.0687) = 156.47, p = 1.466e-5, linear mixed model), amplitude (F(1, 2.702) = 58.028, p = 0.0067, linear mixed model), rise time (F(1, 4.9424) = 11.812, p = 0.0188, linear mixed model) and decay time (F(1,4.9115) = 0.98111, p = 0.3682, linear mixed model) of sIPSCs after the addition of PTX (red dotted line). (E-F) Confocal images of the MDJ labelled with fluorescent markers for VGAT (left) and Gephyrin (middle), and overlayed together (right). The image in (e) is the same animal as in (f), but (f) is at a higher magnification and resolution. Data are represented as mean ± SD.
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(A) Example trace of sIPSC recordings performed with caesium chloride (CsCl) and in the presence of the AMPA and NMDA blockers <t>NBQX</t> <t>and</t> <t>DL-AP5,</t> respectively. (B) Boxplots of sIPSC frequency, amplitude, rise time, and decay time (frequency: 4.73 ± 2.09 Hz; amplitude:-62.5 ± 25.6 pA; rise time; 2.00 ± 0.31 ms; decay time: 5.27 ± 1.34 ms; n = 15 neurons from 5 mice). (C) Example traces of a recorded MDJ-IO neuron before (t=0), 10 minutes after (t=10), and 20 minutes (t=20) after the addition of the GABA receptor blocker picrotoxin (PTX). (D) Time-course of the frequency minutes (F(1,6.0687) = 156.47, p = 1.466e-5, linear mixed model), amplitude (F(1, 2.702) = 58.028, p = 0.0067, linear mixed model), rise time (F(1, 4.9424) = 11.812, p = 0.0188, linear mixed model) and decay time (F(1,4.9115) = 0.98111, p = 0.3682, linear mixed model) of sIPSCs after the addition of PTX (red dotted line). (E-F) Confocal images of the MDJ labelled with fluorescent markers for VGAT (left) and Gephyrin (middle), and overlayed together (right). The image in (e) is the same animal as in (f), but (f) is at a higher magnification and resolution. Data are represented as mean ± SD.
2 3 Dihydroxy 6 Nitro 7 Sulphamoyl 22 Benzo F Quinoxaline, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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2 3 dihydroxy 6 nitro 7 sulfamoyl benzo  (Tocris)
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(A) Example trace of sIPSC recordings performed with caesium chloride (CsCl) and in the presence of the AMPA and NMDA blockers <t>NBQX</t> <t>and</t> <t>DL-AP5,</t> respectively. (B) Boxplots of sIPSC frequency, amplitude, rise time, and decay time (frequency: 4.73 ± 2.09 Hz; amplitude:-62.5 ± 25.6 pA; rise time; 2.00 ± 0.31 ms; decay time: 5.27 ± 1.34 ms; n = 15 neurons from 5 mice). (C) Example traces of a recorded MDJ-IO neuron before (t=0), 10 minutes after (t=10), and 20 minutes (t=20) after the addition of the GABA receptor blocker picrotoxin (PTX). (D) Time-course of the frequency minutes (F(1,6.0687) = 156.47, p = 1.466e-5, linear mixed model), amplitude (F(1, 2.702) = 58.028, p = 0.0067, linear mixed model), rise time (F(1, 4.9424) = 11.812, p = 0.0188, linear mixed model) and decay time (F(1,4.9115) = 0.98111, p = 0.3682, linear mixed model) of sIPSCs after the addition of PTX (red dotted line). (E-F) Confocal images of the MDJ labelled with fluorescent markers for VGAT (left) and Gephyrin (middle), and overlayed together (right). The image in (e) is the same animal as in (f), but (f) is at a higher magnification and resolution. Data are represented as mean ± SD.
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(A) Example trace of sIPSC recordings performed with caesium chloride (CsCl) and in the presence of the AMPA and NMDA blockers <t>NBQX</t> <t>and</t> <t>DL-AP5,</t> respectively. (B) Boxplots of sIPSC frequency, amplitude, rise time, and decay time (frequency: 4.73 ± 2.09 Hz; amplitude:-62.5 ± 25.6 pA; rise time; 2.00 ± 0.31 ms; decay time: 5.27 ± 1.34 ms; n = 15 neurons from 5 mice). (C) Example traces of a recorded MDJ-IO neuron before (t=0), 10 minutes after (t=10), and 20 minutes (t=20) after the addition of the GABA receptor blocker picrotoxin (PTX). (D) Time-course of the frequency minutes (F(1,6.0687) = 156.47, p = 1.466e-5, linear mixed model), amplitude (F(1, 2.702) = 58.028, p = 0.0067, linear mixed model), rise time (F(1, 4.9424) = 11.812, p = 0.0188, linear mixed model) and decay time (F(1,4.9115) = 0.98111, p = 0.3682, linear mixed model) of sIPSCs after the addition of PTX (red dotted line). (E-F) Confocal images of the MDJ labelled with fluorescent markers for VGAT (left) and Gephyrin (middle), and overlayed together (right). The image in (e) is the same animal as in (f), but (f) is at a higher magnification and resolution. Data are represented as mean ± SD.
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(A) Example trace of sIPSC recordings performed with caesium chloride (CsCl) and in the presence of the AMPA and NMDA blockers <t>NBQX</t> <t>and</t> <t>DL-AP5,</t> respectively. (B) Boxplots of sIPSC frequency, amplitude, rise time, and decay time (frequency: 4.73 ± 2.09 Hz; amplitude:-62.5 ± 25.6 pA; rise time; 2.00 ± 0.31 ms; decay time: 5.27 ± 1.34 ms; n = 15 neurons from 5 mice). (C) Example traces of a recorded MDJ-IO neuron before (t=0), 10 minutes after (t=10), and 20 minutes (t=20) after the addition of the GABA receptor blocker picrotoxin (PTX). (D) Time-course of the frequency minutes (F(1,6.0687) = 156.47, p = 1.466e-5, linear mixed model), amplitude (F(1, 2.702) = 58.028, p = 0.0067, linear mixed model), rise time (F(1, 4.9424) = 11.812, p = 0.0188, linear mixed model) and decay time (F(1,4.9115) = 0.98111, p = 0.3682, linear mixed model) of sIPSCs after the addition of PTX (red dotted line). (E-F) Confocal images of the MDJ labelled with fluorescent markers for VGAT (left) and Gephyrin (middle), and overlayed together (right). The image in (e) is the same animal as in (f), but (f) is at a higher magnification and resolution. Data are represented as mean ± SD.
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(A) Example trace of sIPSC recordings performed with caesium chloride (CsCl) and in the presence of the AMPA and NMDA blockers NBQX and DL-AP5, respectively. (B) Boxplots of sIPSC frequency, amplitude, rise time, and decay time (frequency: 4.73 ± 2.09 Hz; amplitude:-62.5 ± 25.6 pA; rise time; 2.00 ± 0.31 ms; decay time: 5.27 ± 1.34 ms; n = 15 neurons from 5 mice). (C) Example traces of a recorded MDJ-IO neuron before (t=0), 10 minutes after (t=10), and 20 minutes (t=20) after the addition of the GABA receptor blocker picrotoxin (PTX). (D) Time-course of the frequency minutes (F(1,6.0687) = 156.47, p = 1.466e-5, linear mixed model), amplitude (F(1, 2.702) = 58.028, p = 0.0067, linear mixed model), rise time (F(1, 4.9424) = 11.812, p = 0.0188, linear mixed model) and decay time (F(1,4.9115) = 0.98111, p = 0.3682, linear mixed model) of sIPSCs after the addition of PTX (red dotted line). (E-F) Confocal images of the MDJ labelled with fluorescent markers for VGAT (left) and Gephyrin (middle), and overlayed together (right). The image in (e) is the same animal as in (f), but (f) is at a higher magnification and resolution. Data are represented as mean ± SD.

Journal: bioRxiv

Article Title: Electrophysiological properties of mesodiencephalic junction neurons projecting to the inferior olive

doi: 10.64898/2026.04.10.717667

Figure Lengend Snippet: (A) Example trace of sIPSC recordings performed with caesium chloride (CsCl) and in the presence of the AMPA and NMDA blockers NBQX and DL-AP5, respectively. (B) Boxplots of sIPSC frequency, amplitude, rise time, and decay time (frequency: 4.73 ± 2.09 Hz; amplitude:-62.5 ± 25.6 pA; rise time; 2.00 ± 0.31 ms; decay time: 5.27 ± 1.34 ms; n = 15 neurons from 5 mice). (C) Example traces of a recorded MDJ-IO neuron before (t=0), 10 minutes after (t=10), and 20 minutes (t=20) after the addition of the GABA receptor blocker picrotoxin (PTX). (D) Time-course of the frequency minutes (F(1,6.0687) = 156.47, p = 1.466e-5, linear mixed model), amplitude (F(1, 2.702) = 58.028, p = 0.0067, linear mixed model), rise time (F(1, 4.9424) = 11.812, p = 0.0188, linear mixed model) and decay time (F(1,4.9115) = 0.98111, p = 0.3682, linear mixed model) of sIPSCs after the addition of PTX (red dotted line). (E-F) Confocal images of the MDJ labelled with fluorescent markers for VGAT (left) and Gephyrin (middle), and overlayed together (right). The image in (e) is the same animal as in (f), but (f) is at a higher magnification and resolution. Data are represented as mean ± SD.

Article Snippet: Recordings of sIPSCs were done using a caesium-chloride internal containing in mM: 150 CsCl, 1.5 MgCl2, 0.5 EGTA, 10 HEPES, 4 Na2ATP, 0.3 Na3GTP, 5 Qx-314. sIPSCs were recorded with 1 μM TTX (HelloBio, Bristol, United Kingdom), 20 μM NBQX (Tocris Bioscience, Bristol, United Kingdom), and 50 μM D-AP5 or DL-AP5 (Tocris Bioscience).

Techniques: